Dear Ganesh,
I have just upgraded a customer from 10.0 SP14 to 10.1 SP12 which is almost a similar jump than yours. I haven't had major issues and most minors where already corrected with notes from SP13/SP14.
Anyway, I wouldn't say that there is no major issue in your case since it depends on your system. The upgrade I am talking about was in SAP standard and with limited configurations even though ARA, ARM, EAM and BRM is used.
Hope this helps.
Regards,
Alessandro